The Bills claimed their second win of the season, after winning their opening game 31-10 against the mighty Los Angeles Rams on September 8.
Stefon Diggs shined for the three touchdown winners, as did quarterback Josh Allen. He finished his night work with a 317-yard pass. It even stayed on the sidelines during the fourth quarter, due to its comfortable lead.
In front of Ryan Tanehill he had a much harder game, scoring only 11 out of 17 pass attempts. He was replaced by junior Malik Willis after being the victim of a second interception, against Matt Milano, who then joined the end zone.
Reggie Gilliam also had a fall for the bills.
Allen hit a 300-yard plateau in a game for the fifteenth time in his career.
The Giants suffered a second straight loss, after losing to the New York Giants 21-20 last week.
Bills’ Dane Jackson sustained a neck injury in a collision with a teammate and was taken to hospital for evaluation.
In another NFL game Monday night, the Philadelphia Eagles defeated the Minnesota Vikings 24-7.